Brain Circuits Split Choices Between Sugar, Fat Cravings

Brain Circuits Split Choices Between Sugar, Fat CravingsA new study reveals that the brain uses two distinct neural pathways to regulate sugar and fat intake. In mice, glucoprivation—a drop in blood sugar levels—activates separate circuits in the hypothalamus: AMPK-regulated CRH neurons drive high-carbohydrate consumption, while MC4R-expressing neurons promote high-fat food intake.