Boosting Sleep Ripples Helps Preserve Memories Normally Forgotten

Boosting Sleep Ripples Helps Preserve Memories Normally ForgottenA new study shows that precisely manipulating brain activity during sleep can help mice retain memories that would normally fade, offering a potential pathway for treating memory loss conditions. Researchers identified a specific sleep-related pattern—large sharp-wave ripples—that signals when new experiences are being transferred from the hippocampus to the neocortex for long-term storage. By boosting these ripples at just the right moment using optogenetics, scientists enabled mice to remember brief encounters they would typically forget.

Losing Myelin Scrambles the Brain’s Sensory Signals

Losing Myelin Scrambles the Brain’s Sensory SignalsNew research reveals that even a small loss of myelin—the protective coating around neurons—can severely disrupt how the brain sends and interprets sensory information. Studying corticothalamic circuits in mice, scientists found that when the first segment of myelin closest to the neuron’s cell body was degraded, nerve signals slowed and lost their crucial “first wave,” altering how sensory information was encoded.