Category: Science
Dopamine Imbalance in the Brain May Drive Trichotillomania
A new study using SAPAP3 knockout mice sheds light on the brain mechanisms that may drive trichotillomania, or hair-pulling disorder. These mice displayed compulsive grooming, heightened aggression, and stress-sensitive behaviors, mirroring human TTM traits—particularly in females.
Bipolar Mood Shifts Linked to Insulin Signaling in the Pancreas
A new study uncovers a pancreas–hippocampus feedback loop that may help explain mood swings in bipolar disorder. Using patient-derived pancreatic islets, researchers found reduced insulin secretion linked to elevated RORβ, a bipolar risk gene.
Boosting Prefrontal Dopamine Shows Promise in Cutting Alcohol Use
A new study reveals that tolcapone, a dopamine-enhancing drug, strengthens brain circuits involved in self-control while reducing alcohol intake in people with alcohol use disorder (AUD). The drug boosts activity in the inferior frontal gyrus, part of the prefrontal cortex, which supports inhibitory control.
Caffeine in the Morning Gives the Biggest Boost to Mood
A large real-world study of 236 young adults found that caffeine significantly boosts positive emotions, particularly in the morning. Participants who had coffee or another caffeinated drink reported feeling happier and more enthusiastic compared to mornings without caffeine.
Highly Sensitive People Face Greater Mental Health Risks
A large-scale meta-analysis of 33 studies has shown that highly sensitive individuals are more prone to common mental health problems, including depression, anxiety, PTSD, and avoidant personality disorder. Sensitivity was defined as a heightened responsiveness to environmental and emotional cues, making people more vulnerable but also more receptive to positive experiences and therapy.
Bacteria and Viruses Join Forces in New Cancer-Killing Therapy
Researchers have developed CAPPSID, a novel cancer therapy that teams bacteria and viruses to infiltrate and destroy tumors. The system hides an oncolytic virus inside Salmonella typhimurium, which naturally migrates into tumors, shielding the virus from immune detection.
